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Our studies focus mainly on morphological and functional evaluation of pulmonary inflammation in clinical and experimental models using chest computed tomography (CT) and positron emission tomography with CT (PET-CT) as imaging tools. We use PET-CT to characterize biological processes at the cellular and molecular levels to investigate pulmonary inflammation’s physiopathological mechanisms. These studies are based on the assumption that the development of inflammation in the lung is prior to the development of tomographic changes, and it may be identified non-invasively. Our group also develops computer-aided diagnosis (CAD) systems for automated semantic segmentation, classification, and quantification of pulmonary involvement using deep learning algorithms.
Keywords: pulmonary inflammation, computed tomography, PET-CT, molecular imaging, artificial intelligence
EDUCATION
MD, Medicine, Federal University of Rio de Janeiro, Brazil
PhD, Department of Radiology, Federal University of Rio de Janeiro, Brazil
Postdoctoral fellow, University of Pittsburgh, USA
INVESTIGATION AREAS
Internal Medicine
ADITIONAL INFORMATION
Carvalho ARS, Guimarães A, Garcia TSO, Madeira Werberich G, Ceotto VF, Bozza FA, Rodrigues RS, Pinto JSF, Schmitt WR, Zin WA, França M. Estimating COVID-19 Pneumonia Extent and Severity From Chest Computed Tomography. Front Physiol. 2021 Feb 15;12:617657. PMID: 33658944; PMCID: PMC7917083.
doi: 10.3389/fphys.2021.617657
Carvalho ARS, Guimarães A, Werberich GM, de Castro SN, Pinto JSF, Schmitt WR, França M, Bozza FA, Guimarães BLDS, Zin WA, Rodrigues RS. COVID-19 Chest Computed Tomography to Stratify Severity and Disease Extension by Artificial Neural Network Computer-Aided Diagnosis. Front Med (Lausanne). 2020 Dec 4;7:577609. PMID: 33344471; PMCID: PMC7746855.
doi: 10.3389/fmed.2020.577609
Carvalho ARS, Guimarães AR, Sztajnbok FR, Rodrigues RS, Silva BRA, Lopes AJ, Zin WA, Almeida I, França MM. Automatic Quantification of Interstitial Lung Disease From Chest Computed Tomography in Systemic Sclerosis. Front Med (Lausanne). 2020 Sep 25;7:577739. PMID: 33102508; PMCID: PMC7546366.
doi: 10.3389/fmed.2020.577739
Wang LM, Wu Q, Kirk RA, Horn KP, Ebada Salem AH, Hoffman JM, Yap JT, Sonnen JA, Towner RA, Bozza FA, Rodrigues RS, Morton KA. Lipopolysaccharide endotoxemia induces amyloid-β and p-tau formation in the rat brain. Am J Nucl Med Mol Imaging. 2018 Apr 25;8(2):86-99. PMID: 29755842; PMCID: PMC5944824.
Disponível em Am J Nucl Med Mol Imaging
Silva BRA, Rodrigues RS, Rufino R, Costa CH, Vilela VS, Levy RA, Guimarães ARM, Carvalho ARS, Lopes AJ. Computed tomography trachea volumetry in patients with scleroderma: Association with clinical and functional findings. PLoS One. 2018 Aug 1;13(8):e0200754. PMID: 30067820; PMCID: PMC6070209.
doi: 10.1371/journal.pone.0200754
24/01/2024
