Stevens Rehen is a Professor of Biological Sciences at the Federal University of Rio de Janeiro and a neuroscientist at IDOR, Brazil. Affiliated Member of the Latin American Academy of Sciences and the Academy of Sciences for the Developing World (TWAS). Fellow of the PEW Latin American Program in Biomedical Sciences. International Fiocruz Servier Award for the Neurosciences, Fulbright Visiting Professor Award. He served as President of the Brazilian Society for Neuroscience and Behavior. His main research areas include viral infection in the developing brain and the effects of psychedelics in human neural cells.
Analyses of the therapeutic effects of psychedelics by using human stem cells, organoids, and C. elegans. Studies of viral infection in the human brain tissue. Generation of human sensory neurons in a dish.
Keywords: human induced pluripotent stem cells, brain organoids, neurospheres, neuroscience, Zika virus
Federal University of Rio de Janeiro, Ph.D., Biological Sciences
University of California in San Diego, Postdoctoral Training, Neuroscience
The Scripps Research Institute, Postdoctoral Training, Neuroscience
AWARDS AND HONORS
Fulbright Visiting Professor Award (2021)
International Fiocruz Servier Award for the Neurosciencesr (2018)
Affiliated Member of Latin American Academy of Sciences (2017)
Affiliate Member, World Academy of Sciences for the developing countries (TWAS) (2009)
Pew Latin American Fellow, Pew Latin American Program in the Biomedical Sciences (2000)
Trindade P, Nascimento JM, Casas BS, Monteverde T, Gasparotto J, Ribeiro CT, Devalle S, Sauma D, Moreira JCF, Gelain DP, Porciuncula LO, Palma V, Martins-de-Souza D, Rehen SK. Induced pluripotent stem cell-derived astrocytes from patients with schizophrenia exhibit an inflammatory phenotype that affects vascularization. Mol Psychiatry. 2022 Oct 24. Epub ahead of print. PMID: 36280751.
Ornelas IM, Cini FA, Wießner I, Marcos E, Araújo DB, Goto-Silva L, Nascimento J, Silva SRB, Costa MN, Falchi M, Olivieri R, Palhano-Fontes F, Sequerra E, Martins-de-Souza D, Feilding A, Rennó-Costa C, Tófoli LF, Rehen SK, Ribeiro S. Nootropic effects of LSD: Behavioral, molecular and computational evidence. Exp Neurol. 2022 Oct;356:114148. Epub 2022 Jun 19. PMID: 35732217.
Pedrosa CDSG, Souza LRQ, Gomes TA, de Lima CVF, Ledur PF, Karmirian K, Barbeito-Andres J, Costa MDN, Higa LM, Rossi ÁD, Bellio M, Tanuri A, Prata-Barbosa A, Tovar-Moll F, Garcez PP, Lara FA, Molica RJR, Rehen SK. The cyanobacterial saxitoxin exacerbates neural cell death and brain malformations induced by Zika virus. PLoS Negl Trop Dis. 2020 Mar 12;14(3):e0008060. PMID: 32163415; PMCID: PMC7067372.
Dakic V, Minardi Nascimento J, Costa Sartore R, Maciel RM, de Araujo DB, Ribeiro S, Martins-de-Souza D, Rehen SK. Short term changes in the proteome of human cerebral organoids induced by 5-MeO-DMT. Sci Rep. 2017 Oct 9;7(1):12863. PMID: 28993683; PMCID: PMC5634411.
Garcez PP, Loiola EC, Madeiro da Costa R, Higa LM, Trindade P, Delvecchio R, Nascimento JM, Brindeiro R, Tanuri A, Rehen SK. Zika virus impairs growth in human neurospheres and brain organoids. Science. 2016 May 13;352(6287):816-8. Epub 2016 Apr 10. PMID: 27064148.
Characterized by several behavioral and cognitive symptoms, schizophrenia is a mental disorder that affects about 0.5 to 1% of the world’s population. The mechanisms involved in the onset of the disease are still unclear, but deficits in neurological development, changes in the neurotransmission system, and immunological disorders are conditions related to the diagnosis. To further […]
A study with the participation of IDOR discovered positive actions of lipoxin A4 on cognitive brain functions and the endocannabinoid system. Researchers from the D’Or Institute for Research and Education (IDOR) have just published a study in the scientific journal Translational Psychiatry that sought to elucidate the mechanisms involved in cognitive deficits in human aging, […]