Stevens Rehen

Stevens Rehen

About

Stevens Rehen is a Professor of Biological Sciences at the Federal University of Rio de Janeiro and a neuroscientist at IDOR, Brazil. Affiliated Member of the Latin American Academy of Sciences and the Academy of Sciences for the Developing World (TWAS). Fellow of the PEW Latin American Program in Biomedical Sciences. International Fiocruz Servier Award for the Neurosciences, Fulbright Visiting Professor Award. He served as President of the Brazilian Society for Neuroscience and Behavior. His main research areas include viral infection in the developing brain and the effects of psychedelics in human neural cells.

Research

Analyses of the therapeutic effects of psychedelics by using human stem cells, organoids, and C. elegans. Studies of viral infection in the human brain tissue. Generation of human sensory neurons in a dish.

Keywords: human induced pluripotent stem cells, brain organoids, neurospheres, neuroscience, Zika virus

EDUCATION

Federal University of Rio de Janeiro, Ph.D., Biological Sciences

University of California in San Diego, Postdoctoral Training, Neuroscience

The Scripps Research Institute, Postdoctoral Training, Neuroscience

INVESTIGATION AREAS

Neurosciences

Neurology

ADITIONAL INFORMATION

AWARDS AND HONORS

Fulbright Visiting Professor Award (2021)

International Fiocruz Servier Award for the Neurosciencesr (2018)

Affiliated Member of Latin American Academy of Sciences (2017)

Affiliate Member, World Academy of Sciences for the developing countries (TWAS) (2009)

Pew Latin American Fellow, Pew Latin American Program in the Biomedical Sciences (2000)

Selected Publications

Pedrosa CDSG, Souza LRQ, Gomes TA, de Lima CVF, Ledur PF, Karmirian K, Barbeito-Andres J, Costa MDN, Higa LM, Rossi ÁD, Bellio M, Tanuri A, Prata-Barbosa A, Tovar-Moll F, Garcez PP, Lara FA, Molica RJR, Rehen SK. The cyanobacterial saxitoxin exacerbates neural cell death and brain malformations induced by Zika virus. PLoS Negl Trop Dis. 2020 Mar 12;14(3):e0008060.
doi: 10.1371/journal.pntd.0008060. PMID: 32163415; PMCID: PMC7067372.

Ledur PF, Karmirian K, Pedrosa CDSG, Souza LRQ, Assis-de-Lemos G, Martins TM, Ferreira JCCG, de Azevedo Reis GF, Silva ES, Silva D, Salerno JA, Ornelas IM, Devalle S, Madeiro da Costa RF, Goto-Silva L, Higa LM, Melo A, Tanuri A, Chimelli L, Murata MM, Garcez PP, Filippi-Chiela EC, Galina A, Borges HL, Rehen SK. Zika virus infection leads to mitochondrial failure, oxidative stress and DNA damage in human iPSC-derived astrocytes. Sci Rep. 2020 Jan 27;10(1):1218.
doi: 10.1038/s41598-020-57914-x. PMID: 31988337; PMCID: PMC6985105.

Guimarães MZP, De Vecchi R, Vitória G, Sochacki JK, Paulsen BS, Lima I, Rodrigues da Silva F, da Costa RFM, Castro NG, Breton L, Rehen SK. Generation of iPSC-Derived Human Peripheral Sensory Neurons Releasing Substance P Elicited by TRPV1 Agonists. Front Mol Neurosci. 2018 Aug 22;11:277.
doi: 10.3389/fnmol.2018.00277. PMID: 30186108; PMCID: PMC6113370.

Garcez PP, Loiola EC, Madeiro da Costa R, Higa LM, Trindade P, Delvecchio R, Nascimento JM, Brindeiro R, Tanuri A, Rehen SK. Zika virus impairs growth in human neurospheres and brain organoids. Science. 2016 May 13;352(6287):816-8.
doi: 10.1126/science.aaf6116. Epub 2016 Apr 10. PMID: 27064148.

Dakic V, Minardi Nascimento J, Costa Sartore R, Maciel RM, de Araujo DB, Ribeiro S, Martins-de-Souza D, Rehen SK. Short term changes in the proteome of human cerebral organoids induced by 5-MeO-DMT. Sci Rep. 2017 Oct 9;7(1):12863.
doi: 10.1038/s41598-017-12779-5. PMID: 28993683; PMCID: PMC5634411.

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