Daniel´s main expertise is in mass spectrometry-based proteomics and metabolomics and systems biology in silico, employed in clinical and pre-clinical models for psychiatric disorders. His lab also focuses on understanding the involvement of glial cells in the development of diseases such as schizophrenia and depression and their treatment including traditional antipsychotics and cannabinoids. Searching for protein and metabolite biomarkers associated with these disorders in human fluids is also one of the focuses of his group. More recently,Daniel´s group has been investigating how does COVID-19 affects the human brain.
Keywords: Proteomics, metabolomics, biomarkers, psychiatry, mass spectrometry
Ph.D. - University of Campinas, Brazil
Post-doc - Max Planck Institute of Psychiatry, Germany
Post-doc - University of Cambridge, United Kingdom
AWARDS AND HONORS
Elected as Affiliated Member of the São Paulo Academy of Sciences (ACIESP) (2019)
Elected as Affiliated Member of the Brazilian Academy of Sciences (ABC) (2017)
Congratulation Vote from the University Council's (2016)
CNPq Research Productivity Fellowship (2015)
Best PhD thesis of the postgraduate program “Molecular and Functional Biology” (2009)
Falvella ACB, Smith BJ, Silva-Costa LC, Valença AGF, Crunfli F, Zuardi AW, Hallak JE, Crippa JA, de Almeida V, Martins-de-Souza D. Cannabidiol Displays Proteomic Similarities to Antipsychotics in Cuprizone-Exposed Human Oligodendrocytic Cell Line MO3.13. Front Mol Neurosci. 2021 May 28;14:673144.
Garcia-Rosa S, Carvalho BS, Guest PC, Steiner J, Martins-de-Souza D. Blood plasma proteomic modulation induced by olanzapine and risperidone in schizophrenia patients. Proteomics. 2020 Jul 30;224:103813.
Nascimento JM, Saia-Cereda VM, Sartore RC, da Costa RM, Schitine CS,Freitas HR, Murgu M, de Melo Reis RA, Rehen SK, Martins-de-Souza D. Human Cerebral Organoids and Fetal Brain Tissue Share Proteomic Similarities. Front Cell Dev Biol. 2019 Nov 28;7:303.
Cassoli JS, Brandão-Teles C, G Santana A, H M F Souza G, Martins-de-Souza D. Ion Mobility-Enhanced Data-Independent Acquisitions Enable a Deep Proteomic Landscape of Oligodendrocytes. Proteomics. 2017 Nov;17(21).
Martins-de-Souza D, Maccarrone G, Ising M, Kloiber S, Lucae S, Holsboer F, Turck CW. Blood mononuclear cell proteome suggests integrin and Ras signaling as critical pathways for antidepressant treatment response. Biol Psychiatry. 2014 Oct 1;76(7):e15-7.
A study conducted in partnership with the D’Or Institute for Research and Education (IDOR), Federal University of São Paulo (UNIFESP), Federal University of Rio de Janeiro (UFRJ), and State University of Campinas (Unicamp), published in the scientific journal Cell & Bioscience demonstrated protein alterations in the nervous system that may be involved in the onset […]
Characterized by several behavioral and cognitive symptoms, schizophrenia is a mental disorder that affects about 0.5 to 1% of the world’s population. The mechanisms involved in the onset of the disease are still unclear, but deficits in neurological development, changes in the neurotransmission system, and immunological disorders are conditions related to the diagnosis. To further […]
A study conducted in partnership with IDOR sought to elucidate biomarkers of the onset of late-life depression. According to the World Health Organization (WHO), depressive disorders have a higher prevalence in adults between 55 and 74 years old. Severe depression in the elderly, also called late-life depression (LLD), has a prevalence of 9 to 45%. […]