In recent decades, science has advanced extraordinarily with the development of technologies capable of studying our genes and how they are expressed in cells. Genomics allows us to identify an individual’s set of genes, while transcriptomics analyzes RNAs—meaning, which genes are “active” at a given moment in a cell.

More recently, an even more powerful innovation has emerged: spatial transcriptomics, also called spatial biology. This technology makes it possible to analyze gene activity while preserving the exact location of each cell in the tissue, revealing a kind of “molecular map” that integrates tissue morphology with genetic activity.

The D’Or Institute for Research and Education (IDOR) has one of the most modern platforms in Latin America for this type of analysis, combining different cutting-edge technologies such as next-generation sequencing (NGS) and the nCounter and GeoMx Digital Spatial Profiler (DSP) platforms. The latter is currently the only one operating in South America with full technical support and a specialized team.

The platform supports researchers from different fields, fostering discoveries in cancer, kidney diseases, neurosciences, immunology, and other specialties. Our commitment is to enable high-precision research that helps transform scientific knowledge into concrete advances for health.

Our services

All services include specialized technical support, experimental consulting, and assistance with data analysis, ensuring technical rigor and scientific quality at every stage of your project.

The Spatial Transcriptomics Platform is an initiative of the D’Or Institute for Research and Education (IDOR), in partnership with Molecular Pathology at Rede D’Or, focused on advanced molecular analysis of tissues and cells, with an emphasis on understanding biological processes in their spatial context.

Located at IDOR-SP, Jabaquara unit, the platform is a center of excellence with a highly qualified multidisciplinary team — composed of scientists, bioinformaticians, and specialists in omics technologies — dedicated to advancing translational science.

We collaborate with academic, clinical, and industry research groups, offering integrated solutions and cutting-edge technologies for studies in oncology, immunology, nephrology, neurosciences, infectious diseases, and more.

Our commitment is to enable highly complex projects with technical rigor, innovation, and real scientific impact.

How the platform is used:

Researchers interested in using the platform can follow these steps:

1. Initial Contact
Send an email to our technical team with a brief description of your project, scientific hypothesis, sample type, and study objectives. Our team will schedule a technical alignment meeting.

2. Planning Meeting
We hold a meeting (in-person or online) to discuss the experimental design, most suitable technologies, sample quantity, controls, analysis strategies, and technical feasibility.

3. Budget and Timeline
The platform team provides a detailed budget, estimated execution timeline, and guidelines for sample shipment and preparation.

4. Project Execution
Analyses are carried out according to the agreed plan, with continuous follow-up. We also offer support in data analysis and results interpretation.

5. Delivery and Support
Data are delivered with a technical report, images, raw files, and support for scientific interpretation and preparation of figures for publication, if needed.

Ongoing Projects

• Analysis of the contribution of FOLR2+ macrophages to the formation of tertiary lymphoid structures in colorectal cancer: PhD thesis by Kianni Freitas under the supervision of Dr. Rodrigo N. Ramos, at IDOR. FAPESP Project: 2024/14683-7

• Spatiotemporal evaluation of the transcriptomic profile of FOLR2+ macrophages in colorectal cancer: PhD thesis by Emmanuelle Quagliato under the supervision of Dr. Rodrigo N. Ramos, at IDOR. FAPESP Project: 2023/08221-8

• Characterization of mononuclear cells from the peripheral blood of multiple myeloma patients. Master’s dissertation by Viviane Jennifer under the supervision of Rodrigo N. Ramos at LIM 31 – Hospital das Clínicas, Faculty of Medicine, University of São Paulo – HCFMUSP

• FOLR2+ macrophages as immunomodulators during the onset of carcinogenesis: a molecular and spatiotemporal approach. FAPESP Young Investigator Project: 2024/04450-5