Our group, in collaboration with Service of Hematology and Cell therapy of the University of São Paulo, investigates the role of cell therapies to treat hematological diseases, including clinical results of allogeneic and autologous hematopoietic stem cell transplantation (HSCT). We are also starting to investigate therapies using genetic modified cells (CAR-T cells) to treat hematological diseases such as leukemias, lymphomas and multiple myeloma and genetic modified Hematopoietic Stem cells to treat sickle cell disease. Our aim is to perform “in vitro” and “in vivo” pre-clinical studies to validate gene delivery with viral vectors and non-viral vectors in lymphocytes, NK and macrophages. We are also interested in establishing a registry with rare hematological diseases such as amyloidoses, Waldenström macroglobulinemia, Erdheim-Chester Disease, Poems Sydrome, Castelman Disease, etc.
Keywords: Autologous and allogeneic HSCT, CAR-T cell therapy, Lymphomas, Leukemias and Multiple Myeloma
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