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The focus of our research is to investigate the molecular basis of leukemogenesis. As a member of the International Consortium on Acute Leukemia (ICAL), we conduct clinical trials exploring strategies to diagnose and treat patients adapted to local resources. We investigate the genome, transcriptome, and proteome to identify molecules relevant to the pathogenesis and response to treatment of AL. The potential candidates are tested using genetically modified cells and mice as models. Our studies analyze not only the leukemic cells but also the bone marrow microenvironment and the cell-to-cell flux of information through microparticles. The use of genetically modified cells for therapy is one of the potential applications of our research.
Keywords: leukemia, acute myeloid leukemia, leukemogenesis, mutation
EDUCATION
Titular Professor of Hematology, Faculty of Medicine, University of São Paulo
INVESTIGATION AREAS
Hematology
ADITIONAL INFORMATION
AWARDS AND HONORS
4th Latin American Novartis Oncology Scientific Award, Novartis Latin America. Role: Supervisor (2011)
Plenary Session Presentation (6 best abstracts) of the American Society of Hematology (ASH) Meeting 2012, Atlanta, GA, USA - Role: Presenter, author (2012)
Rego EM, Wang ZG, Peruzzi D, He LZ, Cordon-Cardo C, Pandolfi PP. Role of promyelocytic leukemia (PML) protein in tumor suppression. J Exp Med. 2001;193(4):521-29.
doi: 10.1084/jem.193.4.521
Rego EM, Kim HT, Ruiz-Argüelles GJ, Undurraga MS, Uriarte Mdel R, Jacomo RH, Gutiérrez- Aguirre H, Melo RA, Bittencourt R, Pasquini R, Pagnano K, Fagundes EM, Chauffaille Mde L, Chiattone CS, Martinez L, Meillón LA, Gómez-Almaguer D, Kwaan HC, Garcés-Eisele J, Gallagher R, Niemeyer CM, Schrier SL, Tallman M, Grimwade D, Ganser A, Berliner N,, Ribeiro RC, Lo-Coco F, Löwenberg B, Sanz MA. Improving acute promyelocytic leukemia (APL) outcome in developing countries through networking, results of the International Consortium on APL. Blood. 2013;121(11):1935-43
doi: 10.1182/blood-2012-08-449918
Barna, M., Pusic, A., Zollo, O. , Costa, M., Kondrashov, N., Rego, E., Rao, P.H., Ruggero, D.. Suppression of Myc oncogenic activity by ribosomal protein haploinsufficiency. Nature 2008; 456, 971–975.
doi: 10.1038/nature07449
Weinhäuser I, Pereira-Martins DA, Ortiz C, Silveira DR, Simões LAA, Bianco TM, Araujo CL, Koury LC, Melo RAM, Bittencourt RI, Pagnano K, Pasquini R, Nunes EC, Fagundes EM, Gloria AB, Kerbauy F, Chauffaille ML, Keating A, Tallman MS, Ribeiro RC, Dillon R, Ganser A, Löwenberg B, Valk P, Lo-Coco F, Sanz MA, Berliner N, Ammatuna E, Lucena-Araujo AR, Schuringa JJ, Rego EM. Reduced SLIT2 is Associated with Increased Cell Proliferation and Arsenic Trioxide Resistance in Acute Promyelocytic Leukemia. Cancers (Basel). 2020 Oct 27;12(11):3134.
doi: 10.3390/cancers12113134
Thomé CH, Ferreira GA, Pereira-Martins DA, Dos Santos GA, Ortiz CA, de Souza LEB, Sobral LM, Silva CLA, Scheucher PS, Gil CD, Leopoldino AM, Silveira DRA, Coelho-Silva JL, Traina F, Koury LC, Melo RAM, Bittencourt R, Pagnano K, Pasquini R, Nunes EC, Fagundes EM, Gloria ABF, Kerbauy FR, Chauffaille ML, Keating A, Tallman MS, Ribeiro RC, Dillon R, Ganser A, Löwenberg B, Valk P, Lo-Coco F, Sanz MA, Berliner N, Faça VM, Rego EM. NTAL is associated with treatment outcome, cell proliferation and differentiation in acute promyelocytic leukemia. Sci Rep. 2020 Jun 25;10(1):10315. PMID: 32587277; PMCID: PMC7316767.
doi: 10.1038/s41598-020-66223-2.
07/12/2023
