Bruno Solano F. Souza

Bruno Solano F. Souza

Research

Our group performs research focused on the: (i) development of cell and gene therapies for currently unmet medical needs; (ii) study of patient-derived induced pluripotent stem cells to model neurodevelopmental disorders/autism spectrum disorders; (iii) application of molecular biology methods applied to biomarker identification and clinical diagnostics. Our main motivation is to cross the translational path and to contribute for improved diagnostics and therapeutics, bringing our findings from bench to the bedside, by combining multidisciplinary approaches, state-of-art technology, preclinical and clinical studies. 

Keywords: cell and gene therapy, iPSC, autism, biomarkers.

EDUCATION

MD, Federal University of Bahia

MSc, Biotechnology, Oswaldo Cruz Foundation - Fiocruz

PhD, Pathology, Federal University of Bahia

INVESTIGATION AREAS

Neurosciences

Oncology

ADITIONAL INFORMATION

Selected Publications

Carolina K V Nonaka, Marília Miranda Franco, Tiago Gräf, Camila Araújo de Lorenzo Barcia, Renata Naves de Ávila Mendonça, Karoline Almeida Felix de Sousa, Leila M C Neiva, Vagner Fosenca, Ana V A Mendes, Renato Santana de Aguiar, Marta Giovanetti, Bruno Solano de Freitas Souza. Genomic Evidence of SARS-CoV-2 Reinfection Involving E484K Spike Mutation, Brazil. Emerg Infect Dis 2021 May;27(5):1522-1524.
doi: 10.1523/JNEUROSCI.1269-16.2016

Kátia Nunes da Silva, André Luiz Nunes Gobatto, Zaquer Suzana Munhoz Costa-Ferro, Bruno Raphael Ribeiro Cavalcante, Alex Cleber Improta Caria, Luciana Souza de Aragão França, Carolina Kymie Vasques Nonaka, Fernanda de Macêdo Lima, Miquéias Lopes-Pacheco, Patricia Rieken Macêdo Rocco & Bruno Solano de Freitas Souza. Is there a place for mesenchymal stromal cell-based therapies in the therapeutic armamentarium against COVID-19? Stem Cell Research & Therapy volume 12, Article number: 425 (2021).
doi: 10.1186/s13287-021-02502-7.

Iasmim Diniz Orge, Victoria L Gadd, Judah Leão Barouh, Erik Aranha Rossi, Rejane Hughes Carvalho, Ian Smith, Kyan James Allahdadi, Bruno Diaz Paredes, Daniela Nascimento Silva, Patrícia Kauanna F Damasceno, Gabriela Louise Sampaio, Stuart J Forbes, Milena Botelho Pereira Soares, Bruno Solano de Freitas Souza. Phenotype instability of hepatocyte-like cells produced by direct reprogramming of mesenchymal stromal cells. Stem Cell Res Ther 11, 154 (2020).
doi: 10.1186/s13287-020-01665-z

Gabriela Louise de Almeida Sampaio, Gabriele Louise Soares Martins, Bruno Diaz Paredes, Carolina Kymie Vasques Nonaka, Katia Nunes da Silva, Erik Aranha Rossi, Ricardo Ribeiro dos Santos, Milena Botelho Pereira Soares, Bruno Solano de Freitas Souza. Generation of an induced pluripotent stem cell line from a patient with autism spectrum disorder and SCN2A haploinsufficiency. Stem Cell Research. Volume 39, August 2019, 101488
doi: 10.1016/j.scr.2019.101488

Bruno S. F. Souza, Gabriela L. A. Sampaio, Ciro S. Pereira, Gubio S. Campos, Silvia I. Sardi, Luiz A. R. Freitas, Claudio P. Figueira, Bruno D. Paredes, Carolina K. V. Nonaka, Carine M. Azevedo, Vinicius P. C. Rocha, Antonio C. Bandeira, Rosalia Mendez-Otero, Ricardo Ribeiro dos Santos & Milena B. P. Soares. Zika virus infection induces mitosis abnormalities and apoptotic cell death of human neural progenitor cells. Scientific reports 6 (1), 1-13. 2016.
doi: 10.1038/srep39775

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