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Our group performs research focused on the: (i) development of cell and gene therapies for currently unmet medical needs; (ii) study of patient-derived induced pluripotent stem cells to model neurodevelopmental disorders/autism spectrum disorders; (iii) application of molecular biology methods applied to biomarker identification and clinical diagnostics. Our main motivation is to cross the translational path and to contribute for improved diagnostics and therapeutics, bringing our findings from bench to the bedside, by combining multidisciplinary approaches, state-of-art technology, preclinical and clinical studies.
Keywords: cell and gene therapy, iPSC, autism, biomarkers.
EDUCATION
MD, Federal University of Bahia
MSc, Biotechnology, Oswaldo Cruz Foundation - Fiocruz
PhD, Pathology, Federal University of Bahia
INVESTIGATION AREAS
Neurosciences
Oncology
ADITIONAL INFORMATION
Nonaka CKV, Franco MM, Gräf T, de Lorenzo Barcia CA, de Ávila Mendonça RN, de Sousa KAF, Neiva LMC, Fosenca V, Mendes AVA, de Aguiar RS, Giovanetti M, de Freitas Souza BS. Genomic Evidence of SARS-CoV-2 Reinfection Involving E484K Spike Mutation, Brazil. Emerg Infect Dis 2021 May;27(5):1522-1524. Epub 2021 Feb 19. PMID: 33605869; PMCID: PMC8084516.
doi: 10.3201/eid2705.210191
da Silva KN, Gobatto ALN, Costa-Ferro ZSM, Cavalcante BRR, Caria ACI, de Aragão França LS, Nonaka CKV, de Macêdo Lima F, Lopes-Pacheco M, Rocco PRM, de Freitas Souza BS. Is there a place for mesenchymal stromal cell-based therapies in the therapeutic armamentarium against COVID-19? Stem Cell Research & Therapy volume 12, Article number: 425 (2021). PMID: 34315546; PMCID: PMC8314259.
doi: 10.1186/s13287-021-02502-7
Orge ID, Gadd VL, Barouh JL, Rossi EA, Carvalho RH, Smith I, Allahdadi KJ, Paredes BD, Silva DN, Damasceno PKF, Sampaio GL, Forbes SJ, Soares MBP, Souza BSF. Phenotype instability of hepatocyte-like cells produced by direct reprogramming of mesenchymal stromal cells. Stem Cell Res Ther 11, 154 (2020). PMID: 32276654; PMCID: PMC7323614.
doi: 10.1186/s13287-020-01665-z
Sampaio GLA, Martins GLS, Paredes BD, Nonaka CKV, da Silva KN, Rossi EA, Dos Santos RR, Soares MBP, Souza BSF. Generation of an induced pluripotent stem cell line from a patient with autism spectrum disorder and SCN2A haploinsufficiency. Stem Cell Research. Volume 39, August 2019, 101488. Epub 2019 Jun 25. PMID: 31272037.
doi: 10.1016/j.scr.2019.101488
Souza BS, Sampaio GL, Pereira CS, Campos GS, Sardi SI, Freitas LA, Figueira CP, Paredes BD, Nonaka CK, Azevedo CM, Rocha VP, Bandeira AC, Mendez-Otero R, Dos Santos RR, Soares MB. Zika virus infection induces mitosis abnormalities and apoptotic cell death of human neural progenitor cells. Scientific reports 6 (1), 1-13. 2016. PMID: 28008958; PMCID: PMC5180086.
doi: 10.1038/srep39775
26/03/2021
