Based in Bahia, IDOR’s Center for Biotechnology and Cell Therapy (CBTC) conducts translational research aimed at making a positive impact on clinical practice.

One of its lines of research involves autism spectrum disorders. Starting with the genetic mapping of children with autism in the Salvador region, scientists have been studying the genetic alterations associated with this condition. Using induced pluripotent stem cells and brain organoids, the team investigates how these genetic mutations impact brain development and is seeking to develop new methods to reverse or slow down autism spectrum disorders through gene therapy and the use of cannabis-based medications.

In the field of oncology, the CBTC’s projects include the study of the cellular mechanisms involved in the development of metastases and the maintenance of tumor stem cells in patients with squamous cell carcinoma. In both cases, the scientists are looking for targets for new anti-tumor therapies and treatments capable of stopping the spread of cancer.

The CBTC is also working to develop new stem cell therapies for the neurological recovery of patients with spinal cord injuries (paraplegics and quadriplegics) and the treatment of sickle cell anemia and other genetic diseases. Finally, the group is dedicated to creating cell therapies to treat chronic liver and heart diseases, in addition to studying the cellular mechanisms of aging and developing strategies to mitigate or reverse the neurological damage that accompanies it.